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Pharmacological action Cinnarizine is a calcium channel blocker class IV with a predominant effect on the brain vessels, a derivative of piperazine.

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That is, any compound or active disclosed herein that has a given charge or can be made to have a given charge (the "first ion(s)") can be combined with any other compouud or active disclosed herein having a charge opposite to that of the first ion(s) or any compound that can be made to have a charge opposite to that of the first ion(s).

Decongestants help to relieve stuffy nose and ear congestion symptoms.

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Thus, in another aspect, certain embodiments provide methods for treating dopamine receptor-mediated disorders in a human or animal subject in need of such treatment comprising administering to said subject an amount of a compound disclosed herein effective to reduce or prevent said disorder in the subject, in combination with at least one additional agent for the treatment of said disorder that is known in the art.

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Compared to the control treatment (CT), the PSE double cocktail treatment (DCT-PSE) exhibited reduced efficacy in terms of stress and anxiety reduction (Q 3, 4, 5).

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This test was done before doses of study drug and 2, 4 and 6 hours after doses of study drug (see FIG.

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Further, the disclosed ionic liquids can be used as carriers for other active compounds, many of which are disclosed herein.

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In an embodiment of the present invention, preferably, the antidepressant is a norepinephrine-reuptake inhibitor, a tricyclic antidepressant, amitriptyline, or, more preferably, amitriptyline hydrochloride.

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The hexadecylpyridinium ion is known to have antibacterial properties and the sulfathiazole is known for the treatment of gonorrhea and other bacterial infections.

Novel compounds and pharmaceutical compositions, certain of which have been found to modulate dopamine receptor have been discovered, together with methods of synthesizing and using the compounds, including methods for the treatment of dopamine receptor-mediated disorders in a patient by administering the compounds.

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In a further aspect, the disclosed subject matter relates to ionic liquid compositions that can be used for or in biological, pharmaceutical, nutritional, cosmetic, industrial, and conunercial compositions.

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Other categories of CNS agents include benzodiazepines, barbiturates, opioids and other addictive drugs, analgesics, antipsychotics and antidepressants, muscle relaxants and nonbenzodiazepines, antispasmolytics, antihistamines and drugs for treatment of neurodegenerative diseases.

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If used for 2 wk or longer, abrupt withdrawal may result in fatigue, nausea, flushing, light-headedness, uncontrolled crying, vomiting, GI upset, panic attack, or nervousness.

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The suspension tablet composition may, in addition to the ingredients described above, contain other ingredients often used in pharmaceutical tablets, including flavoring agents, sweetening agents, flow aids, lubricants or other common tablet adjuvants, as will be apparent to those skilled in the art.

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Norepinephrine-reuptake inhibitors comprise amitriptyline, desmethylamitriptyline, clomipramine, doxepin, imipramine, imipramine-oxide, trimipramine, adinazolam, amiltriptylinoxide, amoxapine, desipramine, maprotiline, nortriptyline, protriptyline, amineptine, butriptyline, demexiptiline, dibenzepin, dimetacrine, dothiepin, fluacizine, iprindole, lofepramine, melitracen, metapramine, norclolipramine, noxiptilin, opipramol, perlapine, pizotyline, propizepine, quinupramine, reboxetine, and tianeptine.

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In another embodiment, the pharmaceutical compositions of the present invention are formulated in compressed forms, such as suspension tablets and effervescent tablets, such that an aqueous form of the pharmaceutical composition is produced upon reaction with water or other diluents upon oral administration.

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From the foregoing description, one skilled in the art can ascertain the essential characteristics of this invention, and without departing from the spirit and scope thereof, can make various changes and modifications of the invention to adapt it to various usages and conditions.

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GUA)) is administered approximately 15 minutes after administration of the CNS agent and PSE; and (3) administration of GUA eliminates the need to use a very high dose of osmoactive polymers (or other osmoactive agents) which can complicate formulation preparation and disturb the subject's physiological osmotic balance.

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Therapeutically effective amount" is used herein with respect to a drug dosage, shall mean that dosage that provides the specific pharmacological response for which the drug is administered in a significant number of subjects in need of such treatment.

An illogical way to control metamphetamine abuse.

The purpose of this example was to determine if the co-administration of pseudoephedrine and guaifenesin with alprazolam has effective in reducing the sedation commonly seen with the administration of alprazolam alone.

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