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Pharmacological action Cinnarizine is a calcium channel blocker class IV with a predominant effect on the brain vessels, a derivative of piperazine.

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Novel compounds and pharmaceutical compositions, certain of which have been found to modulate dopamine receptor have been discovered, together with methods of synthesizing and using the compounds, including methods for the treatment of dopamine receptor-mediated disorders in a patient by administering the compounds.

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Therapeutically effective amount" is used herein with respect to a drug dosage, shall mean that dosage that provides the specific pharmacological response for which the drug is administered in a significant number of subjects in need of such treatment.

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